A senior politician, Khwaja Nazimuddin was Member of the Muslim League Working Committee. In 1934 he was nominated to the Bengal Executive Council and became Home Minister. In 1937 He became the Interior Minster and then from 1943 to 1945 he was Chief Minister of Bengal. He went to America as Indian food Representative in 1945 and also represented India in the League of Nations session of 1945 in Geneva.
After independence he became the first Governor of former East Pakistan and succeeded the Quaid-e-Azam as the second Governor General. After death of Liaquat Ali Khan in 1951, he became the Prime Minister of Pakistan.